The ClC chloride channel, which is found in organisms from bacteria to humans, is linked with some heritable diseases of the muscles and kidney. Mutations in another kind of chloride channel, called ...

When the adrenal gland produces too much aldosterone, this often leads to high blood pressure and kidney damage (hyperaldosteronism). It has only recently emerged that several patients harbor a ...

Nat Clin Pract Nephrol. 2008;4(1):38-46. Our knowledge of the localization, function, physiology and pathophysiology of the kidney-specific Cl-channels and Barttin has been greatly extended in the ...

Nerve cells communicate with each other by means of electrical impulses. To create such an impulse, the cells exchange charged ions with their environment. However, the role played by the ever-present ...

Chloride channels and antiport mechanisms are pivotal for maintaining cellular ion homeostasis and regulating physiological processes such as muscle contraction, epithelial fluid transport and ...

Over-production of nitric oxide and ion disturbance are involved in neuronal apoptosis around the ischemic area following ischemic brain injury. Prof. Quanzhong Chang and team from Zhuhai Campus of ...

Nerve cells communicate with each other by means of electrical impulses. To create such an impulse, the cells exchange charged ions with their environment. However, the role played by the ever-present ...

This is a preview. Log in through your library . Abstract The physiologically indispensable chloride channel (CLC) family is split into two classes of membrane proteins: chloride channels and chloride ...

A mutation in the CLCN6 gene is associated with a novel, particularly severe neurodegenerative disorder. Scientists from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Max ...

Maintenance of cardiac rhythm and pain sensation require the flow of ions across the membranes of all cells. Ion channels, which facilitate this movement, are protein assemblies that penetrate the ...

Rodent ClC-K1 and ClC-K2, and their respective human orthologs ClCKA and ClCKB, are chloride channels specific to the kidney (and inner ear); Barttin is their functionally important subunit. ClC-K1 is ...