Nonsense-mediated RNA decay, or NMD, is an evolutionarily conserved molecular mechanism in which potentially defective messenger RNAs, or mRNAs (genetic material that instructs the body on how to make ...
RNA turnover is necessary for controlling proper mRNA levels posttranscriptionally. In general, RNA degradation is via exoribonucleases that degrade RNA either from the 5′ end to the 3′ end, such as ...
An international collaboration between two Danish and two German teams has delineated that the so-called ‘Arsenite resistance 2 (ARS2)’ protein is capable of inducing early transcription termination ...
The Hippo pathway is an evolutionarily conserved regulator of organ growth and tumorigenesis. In Drosophila, oncogenic RasV12 cooperates with loss-of-cell polarity to promote Hippo pathway-dependent ...
A Northwestern Medicine study has shed light on a critical molecular mechanism underlying amyotrophic lateral sclerosis (ALS) ...
ARS2 recruits via a conserved interaction domain the ZC3H4 restriction factor to chromatin, where it induces transcription termination. NEXT is then recruited through a direct interaction between ...
Dr. Lynne Maquat, a mechanistic biochemist and the director of the University of Rochester Center for RNA Biology, was awarded the 2024 Dr. Paul Janssen Award for Biomedical Research and the 2024 ...
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