Video: The Intrinsic Apoptotic Pathway

Draw the following apoptotic pathway, which operates in human immune cells. A death signal is received when a molecule called Fas binds its cell-surface receptor. The binding of many Fas molecules to receptors causes receptor clustering. The intracellular regions of the receptors, when together, bind proteins called adaptor proteins. These in turn bind to inactive molecules of caspase- 8, which become activated and then activate caspase-3. Once activated, caspase-3 initiates apoptosis. | Numerad